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Clinical stage company driving progress in healthy aging

Topadur Pharma AG is a clinical-stage company developing novel therapies to restore healthy blood flow and stimulate tissue regeneration. We focus on challenging-to-treat age-related diseases characterized by microvascular dysfunction and impaired healing. With a precision-targeted approach, we aim for localized healing with minimal systemic exposure.

Founded to solve the microcirculation challenge

Founded in Switzerland in 2015, Topadur brings together pharma leaders and seasoned scientists driven by a shared belief: that impaired microcirculation is a critical but often overlooked key driver of disease progression. Recognizing a critical unmet need in treatment, Topadur developed a novel approach focused on cGMP regulation – a key mechanism for vascular repair and tissue regeneration.

DualTOP®: Precision repair through dual mechanism of action

Topadur Pharma’s proprietary DualTOP® platform leverages a unique dual mechanism with unprecedented efficacy, inducing vasodilation and stimulating new blood vessel formation to restore oxygen and nutrient supply to tissues. By delivering treatment directly to the affected tissue, DualTOP® is designed to maximize therapeutic benefit while minimizing systemic exposure and reducing side effects.

First-in-class pipeline based on validated science

Backed by preclinical and early clinical validation, our pipeline is anchored by three first-in-class programs addressing significant unmet needs: TOP-N53 for digital ulcers in systemic sclerosis as well as diabetic foot ulcers, and TOP-M119 for androgenetic alopecia.

Our capital-efficient, partnership-driven strategy aims to rapidly advance our assets through Phase 2 clinical trials. Beyond these lead indications, our DualTOP® platform shows promising potential in additional indications where restoring microcirculation could be transformative, fueling a focused, yet expandable innovation pipeline.

Working with purpose for better outcomes

Behind every breakthrough at Topadur is our multidisciplinary team, powered by decades of experience across biotech, medicine, and business.
 
Dr. Reto Naef
Founder & Chief Executive Officer

Dr. Reto Naef brings over 30 years of leadership in pharmaceutical research and drug development. As a former Global Head at the Novartis Institutes for Biomedical Research, he managed international teams of more than 150 scientists, overseeing operations in lead discovery, natural product research, and high-throughput screening. He later served as Head of Scientific Affairs at Novartis Business Services and led major strategic collaborations and policy engagements across the life sciences sector.

Dr. Naef is the inventor on more than 15 patents, has authored over 50 scientific publications, and played a pivotal role in the development of several commercially successful drugs. He holds a PhD in Chemistry from ETH Zurich, completed postdoctoral research at Harvard University under Nobel Laureate E.J. Corey, and earned an Executive MBA from the University of Zurich.

Dr. Reto Naef
Founder & Chief Executive Officer
 
Cornelia Gehrig
Chief Financial Officer a.i.

Cornelia Gehrig has extensive experience leading finance functions across global organizations in diverse industries. With a strong track record in finance, audit, risk management, strategy, business transformation, M&A, and change management, Cornelia has consistently driven value creation and operational excellence.

As former CFO of Bystronic Group, she led global expansion strategies, risk-optimized financing structures, digitalization of financial operations, and cost control initiatives. Earlier roles as CFO at Precious Woods Group and Ionbond Group saw her lead complex restructuring, refinancing, and M&A transactions, as well as IPO preparation and investor relations management.

She currently serves as an active non-executive board member in multiple organizations, where she chairs Audit and Risk Committees, and she advises on governance, transformation, and capital market readiness. She is a Certified Public Accountant and holds a Master’s degree in Economics (lic.rer.pol.) from the University of Bern.

Cornelia Gehrig
Chief Financial Officer a.i.
 
PD Dr. Matthias Schäfer
Chief Innovation Officer
Deputy CEO

With over 20 years of experience in life sciences, PD Dr. Matthias Schäfer combines strong business acumen with deep scientific expertise. In senior roles at pfm medical GmbH and Geistlich Pharma AG, he led international marketing and sales activities, drove clinical strategy initiatives, and launched innovative therapies for both medical devices and pharmaceuticals. In doing so, he ensured clinical impact, sustainable growth, and long-term value creation.

Alongside his industry career, Dr. Schäfer is an external lecturer at ETH Zurich. He has longstanding experience in biomedical sciences and is the author of more than 40 peer-reviewed publications. He earned his PhD in Biology from the University of Würzburg and completed his habilitation at ETH Zurich.

PD Dr. Matthias Schäfer
Chief Innovation Officer
Deputy CEO
 
Dr. Reto Naef
Chair since 2015

Dr. Reto Naef has served as President of the Board since 2015, when he founded Topadur. He is currently a consultant for scientific affairs at Novartis through Prime Force, a role he has held since 2015

Dr. Reto Naef
Chair since 2015
 
Prof. Dr. Günther Wess
Member since 2015

Prof. Dr. Günther Wess has been a member of the Board since 2015. He was Chairman of the Aventis Foundation and was Director of the Helmholtz Center in Munich until 2018. Prior to that, he was Head of Research for Europe at Höchst and Aventis, focusing on cardiovascular disease, diabetes, and oncology.

Prof. Dr. Günther Wess
Member since 2015
 
Dr. Dominik Escher
Member since 2018

Dr. Dominik Escher has been a member of the Board since 2018. He is currently Chairman and Co-founder of CDR-Life and Managing Partner at Pureos Bioventures, both roles held since 2017. He was previously CEO and founder of ESBATech, where he served from 1998 until 2016.

Dr. Dominik Escher
Member since 2018
 
Silvia Scherer
Member since 2020

Silvia Scherer has served on the Board since 2020. She is CEO of Aptissen and previously held CEO roles at Hairstetics and Medaesthetis. From 2003 to 2013, she was Managing Director and General Manager of Anteis.

Silvia Scherer
Member since 2020
 
Dr. Daniel L. Vasella
Vice Chair since 2020

Dr. Daniel L. Vasella has been a member of the Board since 2020. He is Honorary Chairman of the Board of Directors at Novartis, a title he has held since 2013. Previously, he was Chairman of that Board from 1999 to 2013, and CEO of Novartis from 1996 to 2010.

Dr. Daniel L. Vasella
Vice Chair since 2020
 
Cornelia Gehrig
Member since 2024

Cornelia Gehrig joined the Board in 2024. She currently holds board positions at ARYZTA AG, SKAN Group AG, Koras AG, and Ernst Schweizer AG.

Cornelia Gehrig
Member since 2024
 
Prof. Dr. Thierry Carrel
Member since 2025

Prof. Dr. med. Thierry Carrel has served on the Board since 2025. He was Professor and Chair of the Department of Cardiovascular Surgery at the University of Bern from 1999 to 2020, and is one of Switzerland’s most renowned heart and vascular surgeons. He co-founded Swiss Cardio Technologies AG and CoreMedic GmbH, and has served as an advisor to companies including Novostia SA, Xeltis, and Abbott Cardiovascular.

Prof. Dr. Thierry Carrel
Member since 2025
Jay Siegel
(China)
Molecular Design

Prof. Jay S. Siegel is an internationally recognized chemist whose work bridges the U.S., Switzerland, and China. He earned his PhD at Princeton, followed by postdoctoral work in Strasbourg and at ETH Zurich, before joining faculty at UC San Diego and later Zürich. In 2013, he moved to China to become Dean of the School of Pharmaceutical Science & Technology at Tianjin University. Currently he is Professor and Vice President Teaching and Learning at the University of Hong Kong.

His research focuses on molecular design, chemical synthesis, and structural analysis, especially in the realms of supramolecular architectures and stereochemistry.

Prof. Jay S. Siegel is an internationally recognized chemist whose work bridges the U.S., Switzerland, and China. He earned his PhD at Princeton, followed by postdoctoral work in Strasbourg and at ETH Zurich, before joining faculty at UC San Diego and later Zürich. In 2013, he moved to China to become Dean of the School of Pharmaceutical Science & Technology at Tianjin University. Currently he is Professor and Vice President Teaching and Learning at the University of Hong Kong.

His research focuses on molecular design, chemical synthesis, and structural analysis, especially in the realms of supramolecular architectures and stereochemistry.

Roger Schibli
(Switzerland)
Cancer

Prof. Roger Schibli is Full Professor of Radiopharmaceutical Chemistry at ETH Zurich and Head of the Center for Radiopharmaceutical Sciences. He studied chemistry at the University of Basel and earned his PhD at the Paul Scherrer Institute. After a postdoctoral stay at the University of Missouri-Columbia, he joined ETH as Assistant Professor in 2004 and became Full Professor in 2019.

His research focuses on the design, chemical modification, and biological optimization of radiolabeled molecules for targeted tumor diagnosis and therapy, with particular emphasis on PET, SPECT, and theragnostic applications.

Prof. Roger Schibli is Full Professor of Radiopharmaceutical Chemistry at ETH Zurich and Head of the Center for Radiopharmaceutical Sciences. He studied chemistry at the University of Basel and earned his PhD at the Paul Scherrer Institute. After a postdoctoral stay at the University of Missouri-Columbia, he joined ETH as Assistant Professor in 2004 and became Full Professor in 2019.

His research focuses on the design, chemical modification, and biological optimization of radiolabeled molecules for targeted tumor diagnosis and therapy, with particular emphasis on PET, SPECT, and theragnostic applications.

Oliver Distler
(Switzerland)
Systemic Sclerosis and Fibrotic Diseases

Prof. Oliver Distler is Professor of Rheumatology and Head of the Department of Rheumatology at University Hospital Zurich. He also leads the Center for Experimental Rheumatology at the University of Zurich, where he directs translational and clinical research into systemic sclerosis and fibrotic diseases.

His work ranges from uncovering molecular and cellular mechanisms of fibrosis, including the role of non-coding RNAs and biomarkers, to designing and conducting proof-of-concept and Phase 2/3 clinical trials. He has held visiting professorships at Stanford, Gothenburg, and Florence, and plays leading roles in international rheumatology and scleroderma networks such as FOREUM and EUSTAR.

Prof. Oliver Distler is Professor of Rheumatology and Head of the Department of Rheumatology at University Hospital Zurich. He also leads the Center for Experimental Rheumatology at the University of Zurich, where he directs translational and clinical research into systemic sclerosis and fibrotic diseases.

His work ranges from uncovering molecular and cellular mechanisms of fibrosis, including the role of non-coding RNAs and biomarkers, to designing and conducting proof-of-concept and Phase 2/3 clinical trials. He has held visiting professorships at Stanford, Gothenburg, and Florence, and plays leading roles in international rheumatology and scleroderma networks such as FOREUM and EUSTAR.

Hyungil Jung
(Korea)
Technology

Prof. Hyungil Jung is Professor of Biotechnology at Yonsei University, South Korea, where he is also affiliated with the Global Leaders College. He received his PhD in Environmental and Biological Engineering from Cornell University in 2002 and completed both an MS in Food and Biotechnology and a BA in Food Engineering at Yonsei University.

His research focuses on transdermal drug delivery, microneedle technologies, and related biomaterials and pharmaceutics. At Yonsei, he leads a research group dedicated to the development of advanced delivery systems.

Prof. Hyungil Jung is Professor of Biotechnology at Yonsei University, South Korea, where he is also affiliated with the Global Leaders College. He received his PhD in Environmental and Biological Engineering from Cornell University in 2002 and completed both an MS in Food and Biotechnology and a BA in Food Engineering at Yonsei University.

His research focuses on transdermal drug delivery, microneedle technologies, and related biomaterials and pharmaceutics. At Yonsei, he leads a research group dedicated to the development of advanced delivery systems.

Marie-Elise Truchetet
(Bordeaux, France)
Systemic Sclerosis

Prof. Marie-Élise Truchetet is Professor of Rheumatology at the University of Bordeaux and a practicing rheumatologist at CHU Bordeaux, within the Pellegrin hospital group. She is also a member of the ImmunoConcept research unit, where her team focuses on systemic sclerosis and other autoimmune and inflammatory diseases.
She has published widely in the field of systemic sclerosis and contributes to the development of new therapeutic strategies. In recognition of her expertise, she was elected President of EUSTAR (European Scleroderma Trials and Research group) in 2025, where she plays a leading role in coordinating European research efforts on scleroderma.

Prof. Marie-Élise Truchetet is Professor of Rheumatology at the University of Bordeaux and a practicing rheumatologist at CHU Bordeaux, within the Pellegrin hospital group. She is also a member of the ImmunoConcept research unit, where her team focuses on systemic sclerosis and other autoimmune and inflammatory diseases.
She has published widely in the field of systemic sclerosis and contributes to the development of new therapeutic strategies. In recognition of her expertise, she was elected President of EUSTAR (European Scleroderma Trials and Research group) in 2025, where she plays a leading role in coordinating European research efforts on scleroderma.

Yannick Allanore
(Paris, France)
Systemic Sclerosis

Prof. Yannick Allanore is Professor of Rheumatology at Université Paris Cité and a practicing physician at Cochin Hospital in Paris. After a postdoctoral fellowship at Necker Hospital, he established his own research group at the Cochin Institute in 2011 through the ATIP-Avenir program.

His research focuses on systemic sclerosis and chronic fibro-inflammatory diseases, combining genetic approaches, animal models, and biobanks to identify new therapeutic targets and biomarkers. Since 2022, he has also served as Deputy Director of the Cochin Institute and plays a leading role in European research networks on systemic sclerosis (EUSTAR).

Prof. Yannick Allanore is Professor of Rheumatology at Université Paris Cité and a practicing physician at Cochin Hospital in Paris. After a postdoctoral fellowship at Necker Hospital, he established his own research group at the Cochin Institute in 2011 through the ATIP-Avenir program.

His research focuses on systemic sclerosis and chronic fibro-inflammatory diseases, combining genetic approaches, animal models, and biobanks to identify new therapeutic targets and biomarkers. Since 2022, he has also served as Deputy Director of the Cochin Institute and plays a leading role in European research networks on systemic sclerosis (EUSTAR).

Sabine Werner
(Zurich, Switzerland)
Wound Healing

Prof. Sabine Werner is Full Professor of Cell Biology at ETH Zürich, where she has led the Molecular Health Sciences group since 1999. She studied biochemistry in Tübingen and Munich, completed her PhD at the Max Planck Institute for Biochemistry, and worked in Munich and San Francisco before joining ETH.

Her research focuses on the molecular mechanisms of tissue repair and wound healing, with a special interest in their links to cancer and chronic inflammation. She has received several prestigious awards and is a member of the Leopoldina, EMBO, and the European Academy of Sciences.

Prof. Sabine Werner is Full Professor of Cell Biology at ETH Zürich, where she has led the Molecular Health Sciences group since 1999. She studied biochemistry in Tübingen and Munich, completed her PhD at the Max Planck Institute for Biochemistry, and worked in Munich and San Francisco before joining ETH.

Her research focuses on the molecular mechanisms of tissue repair and wound healing, with a special interest in their links to cancer and chronic inflammation. She has received several prestigious awards and is a member of the Leopoldina, EMBO, and the European Academy of Sciences.

Building a global future together

Topadur has built a strong network of international collaborations with globally recognized partners, helping us accelerate the development of therapies for the patients who need them most.

Switzerland

Prof. Oliver Distler | University of Zurich
Lung Fibrosis

Prof. Nicole Lindenblatt | University Hospital Zurich
Wound healing

Prof. Sabine Werner | ETH Zürich
Wound healing

Prof. Matthias Turina | University Hospital Zurich
Oncology

Prof. Martin Pruschy | University of Zurich
Oncology

Prof. Roger Schibli | Paul Scherrer Institute
Radio Oncology

Prof. Michael Scharl | University Hospital Zurich
Inflammatory Bowel Disease, Oncology

Prof. Georgios Imanidis | FHNW University of Applied Sciences
Formulations development

Prof. Jörn Dengjel | University of Fribourg
Proteomics

Prof. Botond Roska | Institute of Molecular and Clinical Ophthalmology Basel
Ophthalmology

Prof. Christian Grimm | University of Zurich
Ophthalmology

France

Prof. Jean-Luc Cracowski | Hospital Center University Grenoble Alps
Wound healing

Prof. Sophie Blaise | Hospital Center University Grenoble Alps
Systemic Sclerosis

Prof. Yannick Allanore | Cochin Hospital Paris
Systemic Sclerosis

Prof. Marie-Elise Truchetet | Hospital Center University Bordeaux
Systemic Sclerosis

Prof. Davide Launay | Hospital Center University Lille
Systemic Sclerosis

Germany

Prof. Ralf Ludwig | University of Lübeck
Skin fibrosis

Spain

Prof. Javier Milara | University of Valencia
Skin and lung fibrosis

Prof. Julio Cortijo | University of Valencia
Skin fibrosis

South Korea

Prof. Hyungil Jung | Yonsei University & Seoul National University
Formulation

Prof. Ohsang Kwon | Yonsei University & Seoul National University
Formulation