Topadur COMPOUNDS
Target cGMP-Enzyme Regulation System to treat aging-related diseases.
Problem
Aging processes are characterized by a reduction in blood circulation and dysregulation in cell-cell communication. The misbalance of cGMP levels leads to diseases like chronic wounds, skin fibrosis, age-related macula degeneration, diabetic retinopathy, colorectal cancer, hair loss and skin aging.
Solution
TOPADUR designed new drugs that target the cGMP-Enzyme Regulation System. TOPADUR’s compounds regulate the activity of sGC and PDE5 enzymes to increase the level of cGMP. This ultimately enables blood circulation and corrects the insufficient cell-cell communication.
Key publications
Ben-YehudaGreenwald et al. A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes. Journalof Investigative Dermatology (2021), doi: 10.1016/j.jid.2020.05.111.
Naef,Tenor & Koch. TOP-N53: A Clinical Drug Candidate for the Treatment ofNon-healing Wounds. Chimia 74 (2020), doi: 10.2533/chimia.2020.814.
